Therapeutic Angiogenesis by Gene Therapy for Critical Limb Ischemia: Choice of Biological Agent
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منابع مشابه
Therapeutic Angiogenesis by Gene Therapy for Critical Limb Ischemia: Choice of Biological Agent
Peripheral artery disease (PAD) is caused by atherosclerosis, hardening and narrowing arteries over time due to buildup of fatty deposit in vascular bed called plaque. Severe blockage of an artery of the lower extremity markedly reduce blood flow, resulting in critical limb ischemia (CLI) manifested by a variety of clinical syndromes including rest pain in the feet or toes, ulcer and gangrene w...
متن کاملHope for Therapeutic Angiogenesis for Patients with Critical Limb Ischemia: from Bench to Bedside
Peripheral arterial disease is a common but under-recognized problem. As the disease progresses, the patient might suffer from rest pain and/or ischemic ulceration critical limb ischemia (CLI). The primary goals for treating the limb symptoms of CLI are to improve functional capacity, exercise performance and qualify of life. Although numerous therapy options can be used for CLI, unfortunately,...
متن کاملTherapeutic angiogenesis for critical limb ischemia: microvascular therapies coming of age.
of Age Therapeutic Angiogenesis for Critical Limb Ischemia: Microvascular Therapies Coming Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.108.784371 2008;118:9-16 Circulation. http://circ.ahajournal...
متن کاملImproving the level of amputation of the lower extremity after therapeutic endovascular intervention for patients with critical limb ischemia
Methods: We conducted a comparative study of two groups of patients suffering from arterial insufficiency of the lower extremities, and the decision taken to amputate above the knee for both of them. A group of patients selected for a therapeutic peripheral intervention, and the effect of this intervention in improving the level of amputation studied and calculated statistically. The study cond...
متن کاملPhase I/IIa clinical trial of therapeutic angiogenesis using hepatocyte growth factor gene transfer to treat critical limb ischemia.
OBJECTIVE To evaluate the safety and feasibility of intramuscular gene transfer using naked plasmid DNA-encoding hepatocyte growth factor (HGF) and to assess its potential therapeutic benefit in patients with critical limb ischemia. METHODS AND RESULTS Gene transfer was performed in 22 patients with critical limb ischemia by intramuscular injection of HGF plasmid, either 2 or 4 mg, 2 times. S...
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ژورنال
عنوان ژورنال: Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry
سال: 2014
ISSN: 1871-5222
DOI: 10.2174/1871522213999131231105139